اثر فعالیت هوازی بیشینه بر تغییرات بیومارکر‌های انقباضی میوکارد ( CK-MBو cTnI) در مردان میانسال مبتلا به سندروم متابولیک

ABSTRACT Background & Objectives: Cardiac biomarkers are used in the diagnosis of heart tissue damage. High serum levels of biomarkers increases the rate of mortality in adults with metabolic syndrome. The purpose of this study was to evaluate the effect of maximal physical exercise on blood levels of troponin I (cTnI) and creatine kinase isoenzymes MB (CK-MB) in middle-aged men with metabolic syndrome. Materials and Methods: Generally, nine patients with previous history of metabolic syndrome disease (MS group) and eight healthy men (H group) performed Balke test (at a constant walking speed of 5.3 km/h while gradient/slope increased every one minute). Blood samples were obtained before, and immediately, 1, and 24 hours after exercise. The data were analyzed using independent t-test and repeated measures ANOVA for different time points. Results: The data indicated that one session of maximal aerobic exercise could significantly increase serum levels of cTnI and CK-MB. Serum level of CK-MB was significantly different between the groups (P<0.032); however, serum level of cTnI was not significantly different between the two groups (P>0.05). Conclusion: Maximal aerobic exercise can elevate serum levels of cTnI and CK-MB, which might be caused by the nature of aerobic exercise and muscle damage due to intense muscular activity. Therefore, physical exercise should be performed cautiously to reduce the symptoms of metabolic syndrome.